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CAS No.: 595-33-5

醋酸甲地孕酮 Catalog No. CSN11374

Synonyms: BDH1298;SC10363;Megestryl Acetate

Megestryl Acetate is a synthetic progesterone analog.

规格	价格	促销价格	库存	数量

400-920-2911

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靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 Progesterone Receptor

IC50:260μM
描述Megestrol acetate was one of the first progestational agents to be evaluated for use in the hormonal therapy of advanced breast cancer. As single-agent therapy, the average overall response rate to megestrol acetate therapy is 30%^[3]. Megestrol acetate doses equal to or lower than 240 mg/day lead to slight weight gain in patients with cancer-associated cachexia^[4]. The mechanism of action of megestrol is believed to involve stimulation of appetite by both direct and indirect pathways and antagonism of the metabolic effects of the principal catabolic cytokines^[5]. The risk of megestrol-induced Cushing syndrome, especially with high doses of the medication, should be considered as a possible adverse effect in patents with renal insufficiency^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.6007 mL
- 13.0036 mL
- 26.0072 mL
- 5 mM
- 0.5201 mL
- 2.6007 mL
- 5.2014 mL
- 10 mM
- 0.2601 mL
- 1.3004 mL
- 2.6007 mL

技术信息

CAS号

595-33-5

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H32O4

运输

蓝冰

分子量

384.51

别名

BDH1298;SC10363;Megestryl Acetate;NSC 71423;Megace;Ovaban;Pallace. Maygace;Megestil;Niagestin;醋酸甲地孕酮

溶解度

DMSO	31.0 mg/mL (80.6 mM)
Water	Insoluble
Ethanol	14.0 mg/mL (36.4 mM)

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